Archive for the ‘Ashkenazi’ Category

Should All Ashkenazi Women Get Tested for BRCA Gene Mutations?

New Study Says Yes Experts Are Divided

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Life-Saving Screening: A radiology technician examines a mammography test.

No family history of cancer? Get tested anyway suggests a recently-published study, but medical experts are deeply divided.

The study indicates that even Ashkenazi women with no family history of the disease but who test positive for a cancer-causing genetic mutation have high rates of breast and ovarian cancer.

At the heart of the dispute is the question of whether all women of Ashkenazi Jewish descent should now get genetic testing to determine if they have the mutations of the BRCA1 or BRCA2 gene. And, if they do get tested, what should they do if the results show mutations?

Ashkenazim are at a particularly high risk for these mutations: One in 40 carries a BRCA mutation as compared to one in 345 in the general population. But until now, the United States Preventive Services Task Force has recommended against routine genetic counseling or BRCA testing for women who had no family history of cancer.

Citing their findings, published September 5 on the website of the Proceedings of the National Academy of Sciences, the studys authors recommended routine screening of all women of Ashkenazi backgrounds for harmful mutations in the BRCA genes. Some prominent experts agree.

I think it is going to be a game changer, said Dr. Harry Ostrer, a noted geneticist at the Albert Einstein College of Medicine, in New York, referring to the study results. I think it puts the U.S. Preventive Services Task Force on notice.

Ostrer said he had just returned from a bar mitzvah, where the study was making waves. People were walking up to me and saying, Gee, I want to be tested. How do I do that? he said.

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Should All Ashkenazi Women Get Tested for BRCA Gene Mutations?

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Mapping the DNA Sequence of Ashkenazi Jews

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Newswise New York, NYSeptember 9, 2014Led by Itsik Peer, associate professor of computer science at Columbia Engineering, a team of researchers has created a data resource that will improve genomic research in the Ashkenazi Jewish population and lead to more effective personalized medicine. The team, which includes experts from 11 labs in the New York City area and Israel, focused on the Ashkenazi Jewish population because of its demographic history of genetic isolation and the resulting abundance of population-specific mutations and high prevalence of rare genetic disorders. The Ashkenazi Jewish population has played an important role in human genetics, with notable successes in gene mapping as well as prenatal and cancer screening. The study was published online on Nature Communications today.

Our study is the first full DNA sequence dataset available for Ashkenazi Jewish genomes, says Peer, who is also a co-chair of the Health Analytics Center at Columbias Institute for Data Sciences and Engineering, as well as a member of its Foundations of Data Science Center. With this comprehensive catalog of mutations present in the Ashkenazi Jewish population, we will be able to more effectively map disease genes onto the genome and thus gain a better understanding of common disorders. We see this study serving as a vehicle for personalized medicine and a model for researchers working with other populations.

To help in his hunt for disease genes, Peer founded The Ashkenazi Genome Consortium (TAGC) in September 2011 with Todd Lencz, an investigator at The Feinstein Institute for Medical Research, director of the Laboratory of Analytic Genomics at the Zucker Hillside Hospital, and associate professor of molecular medicine and psychiatry at the Hofstra North Shore-LIJ School of Medicine. The other TAGC members, who are providing expertise in the diseases they are studying, are: Gil Atzmon, associate professor of medicine and genetics, Albert Einstein College of Medicine (genetics of longevity and diabetes); Lorraine Clark, associate professor of clinical pathology and cell biology and co-director, Personalized Genomic Medicine Laboratory, Columbia University Medical Center, Laurie Ozelius, associate professor at Icahn School of Medicine at Mount Sinai, and Susan Bressman, chair of neurology at Mount Sinai Beth Israel (Parkinsons disease and related neurological phenotypes); Harry Ostrer, professor of pathology, genetics, and pediatrics, Albert Einstein College of Medicine (radiogenomics, cancers and rare genetic disorders); Ken Offit, chief of clinical genetics at Memorial Sloan Kettering Cancer Center (breast, ovarian, colon and prostate cancers, lymphoma); Inga Peter, associate professor of genetics and genomic sciences, and Judy Cho, professor of medicine and professor of genetics and genomic sciences, both at The Mount Sinai Hospital(inflammatory bowel disease); and Ariel Darvasi, vice-dean of The Faculty of Life Sciences at The Hebrew University of Jerusalem (multiple diseases).

Before the TAGC study, data was available for a limited number of DNA markers (only approximately one in every 3000 letters of DNA) that are mostly common in Europeans. The TAGC researchers performed high-depth sequencing of 128 complete genomes of Ashkenazi Jewish healthy individuals. They compared their data to European samples, and found that Ashkenazi Jewish genomes had significantly more mutations that had not yet been mapped. Peer and his team analyzed the raw data and created a comprehensive catalog of mutations present in the Ashkenazi Jewish population.

The TAGC database is already proving useful for clinical genomics, identifying specific new mutations for carrier screening. Lencz explains: TAGC advances the goal of bringing personal genomics to the clinic, as it tells the physician whether a mutation in a patients genome is shared by healthy individuals, and can alleviate concerns that it is causing disease. Without our work, a patients genome sequence is much harder to interpret, and more prone to create false alarms. We have eliminated two thirds of these false alarms.

The TAGC study further enables more effective discovery of disease-causing mutations, since some genetic factors are observable in Ashkenazi individuals but essentially absent elsewhere. Moreover, the demography of the Ashkenazi population, the largest isolated population in the U.S., enables large-scale recruitment of study patients and hence more genetic discoveries than in other well-known isolated populations like the Amish and Hutterites locally, or the Icelanders overseas. The researchers expect that medical insights from studies of specific populations will also be relevant to general populations as well.

The TAGC teams findings also shed light on the long-debated origin of Ashkenazi Jews and Europeans. The genetic data indicates that the Ashkenazi Jewish population was founded in the late medieval times by a small number, effectively only hundreds of individuals, whose descendants expanded rapidly while remaining mostly isolated genetically.

Our analysis shows that Ashkenazi Jewish medieval founders were ethnically admixed, with origins in Europe and in the Middle East, roughly in equal parts, says Shai Carmi, a post-doctoral scientist who works with Peer and who conducted the analysis. TAGC data are more comprehensive than what was previously available, and we believe the data settle the dispute regarding European and Middle Eastern ancestry in Ashkenazi Jews. In addition to illuminating medieval Jewish history, our results further pave the way to better understanding European origins, millennia before. For example, our data provides evidence for todays European population being genetically descendant primarily from late mid-eastern migrations that took place after the last ice age, rather than from the first humans to arrive to the continent, more than 40,000 years ago.

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Mapping the DNA Sequence of Ashkenazi Jews

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New DNA colon cancer test holds hope; R&R rules!

Dr. Mehmet Oz, left, and Dr. Michael Roizen (King Features Syndicate)

Q: I heard there is a DNA test for colon cancer. Can I cancel my colonoscopy? Please?! Stephen G., Colorado Springs, Colorado

A: Sit tight! The news about a fecal DNA test to spot hemoglobin and mutant DNA that might indicate the presence of colon cancer and adenomatous polyps (benign polyps that could turn cancerous) is great news, but it doesn’t eliminate the need for colonoscopies. It may, however, tell you that you need one!

The DNA stool test is an exam for folks 50 and older who have an average risk of colon cancer. Its cost is covered by Medicare and Medicaid; they’re recommending that it be done every three years. Compared with the fecal immunochemical test (FIT), the DNA test is around 93 percent sensitive to 65 variations of malignancies; FIT rates just 73 percent. Also, it specifically detects precancerous lesions 42 percent of the time, while FIT detects only 23 percent.

How you proceed with your regular screening for colon cancer depends on your risks and a discussion with your doctor. If you’ve already had a polyp found and removed during a colonoscopy, if anyone in your family has had colon cancer or adenomatous polyps, if you have irritable-bowel disease or genetic predispositions or if you are black or an Ashkenazi Jew, you may want to get the DNA stool test every year; you’ll need to have a colonoscopy as frequently as your doctor recommends.

If you don’t have extra risk factors for colon cancer, you still may want to do the DNA test regularly and have a colonoscopy every 10 years after a base-line scope at age 50 (45 for blacks). Also, talk to your doc about taking two low-dose aspirins a day if you don’t take ’em already; they decrease the risk of colon cancer by over 35 percent.

So, don’t postpone a recommended colonoscopy; it’s a life-saver. A polyp removed never becomes cancerous, and colon cancer caught early has a very good prognosis.

Q: I have 27 vacation days piled up, and if I don’t take them, they’ll expire at the end of the year. I also can skip the time off and get paid for it. That seems smarter. What do you think? Susan B., New York

A: You’re lucky to have paid vacation days; the U.S. is the only advanced country in the world that doesn’t guarantee workers paid vacations. (Every country in the EU mandates at least four weeks off annually.) So if you have days off, take them! You’ll be much happier and healthier, and a more productive employee. (One Cincinnati janitorial firm reduced its employee turnover rate from 360 percent to 60 percent and increased productivity by introducing a week’s vacation.)

Unfortunately, many Americans are like you, Susan, and don’t take vacations even when they’re offered! American workers left an estimated 577,212,000 vacation days untaken in 2013! And if you do take time off, 67 percent of you are still in contact with your office. The 1950s had a vision of an automated future that gave you loads of free time. That future is here and what do you get from all that advanced technology? MORE TIME TO WORK MORE!

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New DNA colon cancer test holds hope; R&R rules!

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Study: Test all women of Ashkenazi descent for BRCA defect

Image via Shutterstock.com

All women of Ashkenazi descent should be screened from age 30 for the BRCA gene mutation that causes breast cancer, an Israeli study recommends.

The study, by a research team headed by Ephrat Levy-Lahad of Shaare Zedek Medical Center, was published Friday in thejournalProceedings of the National Academy of Sciences of the United States of America.

Until now, Ashkenazi women have been tested for the BRCA1 and BRCA2 genes only if a close blood relative had breast or ovarian cancer or were identified as carrying the gene.

The research was conducted on a random group of Jewish women of Ashkenazi origin who did not necessarily have a family history of the disease.

Many of the women identified during the study as being mutation carriers would not have known otherwise, according to the study. The mutation can be handed down to women through their fathers.

We welcome your feedback.

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Study: Test all women of Ashkenazi descent for BRCA defect

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New Study Recommends All Ashkenazi Women Be Screened for BRCA

1 in 40 Ashkenazi Jews Carries Gene Mutation By JTA

Published September 08, 2014.

All women of Ashkenazi descent should be screened from age 30 for the BRCA gene mutation that causes breast cancer, an Israeli study recommends.

The study, by a research team headed by Ephrat Levy-Lahad of Shaare Zedek Medical Center, was published Friday in the journal Proceedings of the National Academy of Sciences of the United States of America.

Until now, Ashkenazi women have been tested for the BRCA1 and BRCA2 genes only if a close blood relative had breast or ovarian cancer or were identified as carrying the gene.

The research was conducted on a random group of Jewish women of Ashkenazi origin who did not necessarily have a family history of the disease.

Many of the women identified during the study as being mutation carriers would not have known otherwise, according to the study. The mutation can be handed down to women through their fathers.

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New Study Recommends All Ashkenazi Women Be Screened for BRCA

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New colon cancer test; vacation rewards

Q: I heard there is a DNA test for colon cancer. Can I cancel my colonoscopy? Please?! Stephen G., Colorado Springs, Colorado

A: Sit tight! The news about a fecal DNA test to spot hemoglobin and mutant DNA that might indicate the presence of colon cancer and adenomatous polyps (benign polyps that could turn cancerous) is great news, but it doesn’t eliminate the need for colonoscopies. It may, however, tell you that you need one!

The DNA stool test is an exam for folks 50 and older who have an average risk of colon cancer. Its cost is covered by Medicare and Medicaid; they’re recommending that it be done every three years. Compared with the fecal immunochemical test (FIT), the DNA test is around 93 percent sensitive to 65 variations of malignancies; FIT rates just 73 percent. Also, it specifically detects precancerous lesions 42 percent of the time, while FIT detects only 23 percent.

How you proceed with your regular screening for colon cancer depends on your risks and a discussion with your doctor. If you’ve already had a polyp found and removed during a colonoscopy, if anyone in your family has had colon cancer or adenomatous polyps, if you have irritable bowel disease or genetic predispositions or if you are black or an Ashkenazi Jew, you may want to get the DNA stool test every year; you’ll need to have a colonoscopy as frequently as your doctor recommends.

If you don’t have extra risk factors for colon cancer, you still may want to do the DNA test regularly and have a colonoscopy every 10 years after a baseline scope at 50 (45 for blacks). Also, talk to your doc about taking two low-dose aspirins a day if you don’t take em already; they decrease the risk of colon cancer by over 35 percent.

So, don’t postpone a recommended colonoscopy; it’s a lifesaver. A polyp removed never becomes cancerous, and colon cancer caught early has a very good prognosis.

Q: I have 27 vacation days piled up, and if I don’t take them, they’ll expire at the end of the year. I also can skip the time off and get paid for it. That seems smarter. What do you think? Susan B., New York

A: You’re lucky to have paid vacation days; the U.S. is the only advanced country in the world that doesn’t guarantee workers paid vacations. (Every country in the EU mandates at least four weeks off annually.) So if you have days off, take them! You’ll be much happier and healthier, and a more productive employee. (One Cincinnati janitorial firm reduced its employee turnover rate from 360 percent to 60 percent and increased productivity by introducing a week’s vacation.)

Unfortunately, many Americans are like you, Susan, and don’t take vacations even when they’re offered! American workers left an estimated 577,212,000 vacation days untaken in 2013! And if you do take time off, 67 percent of you are still in contact with your office. The 1950s had a vision of an automated future that gave you loads of free time. That future is here and what do you get from all that advanced technology? MORE TIME TO WORK MORE!

Take advantage of your vacation time: Disconnect from stress; reconnect with your family, and protect your health. One study of middle-age men (at risk for heart disease) found that those who skipped vacations had a 30 percent higher risk of heart attack than guys who took at least a week off. And women who rarely take time off are eight times more likely to have a heart attack than women who take two vacations a year. Other studies prove that vacations improve marriages and are great times to try to upgrade your habits quitting smoking, getting more exercise, banishing the Five Food Felons.

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New colon cancer test; vacation rewards

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Who are the Ashkenazi Jews? (with pictures)

Why is it racism to tell the truth? Ashkenazi Jews claim by birthright they had a right to take Palestine and treat Palestinians as visitors. The promise God made to Abraham was not made to the sons of Japeth or Ham; it was made to Abraham and his sons, descendants of Shem.

The Ashekenazi who say they are Jews by conversion have abandoned the principal way of determining a Jew’s heritage. All Old Testament lineages were traced through the father, not the mother.

If a Christian says he/she is a Christian and hates their enemies, they are no more Christian than a Jew who says he/she is a Jew and traces their ancestry through women.

The Ashekenazi have abandoned the daily sacrifice required by the Law and replaced it with the commandments of men and not God. It is said that prayers offered in the morning meet the requirement God requires of those that live under the Law. Clearly, that is not true.

The Ashekenazi have allied themselves with idol worshippers and false prophets (the Mormons) and therefore not only have no birthright, but also have have set themselves apart from God. Every king and all false prophets in the Bible who allied with such were punished by the Lord. Mormons mask themselves as Christians, but are blasphemers and Ashekanazi have a lot of people fooled with their masks as well, but they are wolves in sheep’s clothing. They are the Jews who are not Jews in the Bible.

You correctly said that if a person converts to Christianity, then it doesn’t matter what their Jewish ancestry is. But what does matter is that their works match their faith and that they do not pervert the inspired Word of God with man-made doctrines that exist to control others, benefit themselves, and are always fairly obvious because their fruits are always bad.

It is not racism to say Ashekenazi are not Jews by promise, but as in Esther’s day, many Persians converted to Judaism out of fear and became Jews. The idea that Christians would ally themselves with a nation armed with 120 nukes crying about their neighbors who have not one single nuke because they believe God would have His temple on the blood soaked ground soaked with the blood of His Son is an anti-Christ dogma.

Clearly, Paul and Revelation state there will be a new heaven and a new earth, and Zion will come out of that Heaven, not the polluted ruin that is covered with God’s Son’s blood. The Ashekenazi and false Christians have used this propaganda to profit from those poor souls that need to be freed.

In this country where there is not supposed to be a religious test, let a politician say one word about the Ashekenazi or the home they stole, and that politician will never be elected. Yet our president can be called a monkey, a terrorist, the N word, and any other disgusting name and the politician who utters that evil is rewarded.

I hardly think racism can be applied to the Ashekenazi who wield more power with less than 5 percent of the population of our nation of almost 300 million people. Lenin, Marx and Stalin — all engineers of mass murder and communism were all Ashekenazi Jews. I have heard that even Hitler was Ashkenazi. I don’t know.

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Ashkenazi Jewish Children on the rampage YouTube – Video



Ashkenazi Jewish Children on the rampage YouTube
Ashkenazi Jewish Children on the rampage YouTube.

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Angelina Jolie Effect Doubles BRCA Testing; @ProMedicaHealth Cancer Genetics Expert Discusses the Importance of …

Released: 5-Sep-2014 8:00 AM EDT Source Newsroom: ProMedica Contact Information

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New research shows more women are getting tested for BRCA1 and 2 mutations after actress Angelina Jolie revealed she had undergone a prophylactic mastectomy once she found out she was a carrier.

BRCA1 and 2 mutations dramatically increase the risk for breast and ovarian cancer. The mutations, which are found in about 2 4 percent of women, are more likely in those with a family history of breast and ovarian cancer and those with personal risk factors, such as Ashkenazi Jewish descent.

Kelly Morse, a licensed genetic counselor at ProMedica Cancer Institute, says our family history plays a crucial role in our overall health and well-being.

Keeping a file with information about your familys medical history should be a priority for everyone, Morse said. As a parent, passing down detailed notes about your ancestors health to your children can be an invaluable gift. Once a loved one is gone, it becomes very difficult to recall this vital data.

Morse suggests patients begin with the following:

1. Start by making a list of your ancestors and immediate family members. It may be helpful to layout the information in a family tree format. Example: Grandparents Parents Siblings Children Aunts/Uncles Cousins

2. Next to each name write down any major health issues, especially cancer diagnoses in this case, and at what age.

3. It may also be helpful to include notes about your loved ones treatment journey. Including lab work and other tests can be especially helpful as well. These details can help tell the story and impact future care and treatment of you or your family.

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Should All Ashkenazi Women Get Tested for BRCA Gene Mutations?

New Study Says Yes Experts Are Divided Thinkstock Life-Saving Screening: A radiology technician examines a mammography test. No family history of cancer? Get tested anyway suggests a recently-published study, but medical experts are deeply divided. The study indicates that even Ashkenazi women with no family history of the disease but who test positive for a cancer-causing genetic mutation have high rates of breast and ovarian cancer. At the heart of the dispute is the question of whether all women of Ashkenazi Jewish descent should now get genetic testing to determine if they have the mutations of the BRCA1 or BRCA2 gene. And, if they do get tested, what should they do if the results show mutations? Ashkenazim are at a particularly high risk for these mutations: One in 40 carries a BRCA mutation as compared to one in 345 in the general population. But until now, the United States Preventive Services Task Force has recommended against routine genetic counseling or BRCA testing for women who had no family history of cancer. Citing their findings, published September 5 on the website of the Proceedings of the National Academy of Sciences, the studys authors recommended routine screening of all women of Ashkenazi backgrounds for harmful mutations in the BRCA genes. Some prominent experts agree. I think it is going to be a game changer, said Dr. Harry Ostrer, a noted geneticist at the Albert Einstein College of Medicine, in New York, referring to the study results. I think it puts the U.S. Preventive Services Task Force on notice. Ostrer said he had just returned from a bar mitzvah, where the study was making waves. People were walking up to me and saying, Gee, I want to be tested. How do I do that? he said.

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Mapping the DNA Sequence of Ashkenazi Jews

Contact Information Available for logged-in reporters only Newswise New York, NYSeptember 9, 2014Led by Itsik Peer, associate professor of computer science at Columbia Engineering, a team of researchers has created a data resource that will improve genomic research in the Ashkenazi Jewish population and lead to more effective personalized medicine. The team, which includes experts from 11 labs in the New York City area and Israel, focused on the Ashkenazi Jewish population because of its demographic history of genetic isolation and the resulting abundance of population-specific mutations and high prevalence of rare genetic disorders. The Ashkenazi Jewish population has played an important role in human genetics, with notable successes in gene mapping as well as prenatal and cancer screening. The study was published online on Nature Communications today. Our study is the first full DNA sequence dataset available for Ashkenazi Jewish genomes, says Peer, who is also a co-chair of the Health Analytics Center at Columbias Institute for Data Sciences and Engineering, as well as a member of its Foundations of Data Science Center. With this comprehensive catalog of mutations present in the Ashkenazi Jewish population, we will be able to more effectively map disease genes onto the genome and thus gain a better understanding of common disorders. We see this study serving as a vehicle for personalized medicine and a model for researchers working with other populations. To help in his hunt for disease genes, Peer founded The Ashkenazi Genome Consortium (TAGC) in September 2011 with Todd Lencz, an investigator at The Feinstein Institute for Medical Research, director of the Laboratory of Analytic Genomics at the Zucker Hillside Hospital, and associate professor of molecular medicine and psychiatry at the Hofstra North Shore-LIJ School of Medicine. The other TAGC members, who are providing expertise in the diseases they are studying, are: Gil Atzmon, associate professor of medicine and genetics, Albert Einstein College of Medicine (genetics of longevity and diabetes); Lorraine Clark, associate professor of clinical pathology and cell biology and co-director, Personalized Genomic Medicine Laboratory, Columbia University Medical Center, Laurie Ozelius, associate professor at Icahn School of Medicine at Mount Sinai, and Susan Bressman, chair of neurology at Mount Sinai Beth Israel (Parkinsons disease and related neurological phenotypes); Harry Ostrer, professor of pathology, genetics, and pediatrics, Albert Einstein College of Medicine (radiogenomics, cancers and rare genetic disorders); Ken Offit, chief of clinical genetics at Memorial Sloan Kettering Cancer Center (breast, ovarian, colon and prostate cancers, lymphoma); Inga Peter, associate professor of genetics and genomic sciences, and Judy Cho, professor of medicine and professor of genetics and genomic sciences, both at The Mount Sinai Hospital(inflammatory bowel disease); and Ariel Darvasi, vice-dean of The Faculty of Life Sciences at The Hebrew University of Jerusalem (multiple diseases). Before the TAGC study, data was available for a limited number of DNA markers (only approximately one in every 3000 letters of DNA) that are mostly common in Europeans. The TAGC researchers performed high-depth sequencing of 128 complete genomes of Ashkenazi Jewish healthy individuals. They compared their data to European samples, and found that Ashkenazi Jewish genomes had significantly more mutations that had not yet been mapped. Peer and his team analyzed the raw data and created a comprehensive catalog of mutations present in the Ashkenazi Jewish population. The TAGC database is already proving useful for clinical genomics, identifying specific new mutations for carrier screening. Lencz explains: TAGC advances the goal of bringing personal genomics to the clinic, as it tells the physician whether a mutation in a patients genome is shared by healthy individuals, and can alleviate concerns that it is causing disease. Without our work, a patients genome sequence is much harder to interpret, and more prone to create false alarms. We have eliminated two thirds of these false alarms. The TAGC study further enables more effective discovery of disease-causing mutations, since some genetic factors are observable in Ashkenazi individuals but essentially absent elsewhere. Moreover, the demography of the Ashkenazi population, the largest isolated population in the U.S., enables large-scale recruitment of study patients and hence more genetic discoveries than in other well-known isolated populations like the Amish and Hutterites locally, or the Icelanders overseas. The researchers expect that medical insights from studies of specific populations will also be relevant to general populations as well. The TAGC teams findings also shed light on the long-debated origin of Ashkenazi Jews and Europeans. The genetic data indicates that the Ashkenazi Jewish population was founded in the late medieval times by a small number, effectively only hundreds of individuals, whose descendants expanded rapidly while remaining mostly isolated genetically. Our analysis shows that Ashkenazi Jewish medieval founders were ethnically admixed, with origins in Europe and in the Middle East, roughly in equal parts, says Shai Carmi, a post-doctoral scientist who works with Peer and who conducted the analysis. TAGC data are more comprehensive than what was previously available, and we believe the data settle the dispute regarding European and Middle Eastern ancestry in Ashkenazi Jews. In addition to illuminating medieval Jewish history, our results further pave the way to better understanding European origins, millennia before. For example, our data provides evidence for todays European population being genetically descendant primarily from late mid-eastern migrations that took place after the last ice age, rather than from the first humans to arrive to the continent, more than 40,000 years ago.

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New DNA colon cancer test holds hope; R&R rules!

Dr. Mehmet Oz, left, and Dr. Michael Roizen (King Features Syndicate) Q: I heard there is a DNA test for colon cancer. Can I cancel my colonoscopy? Please?! Stephen G., Colorado Springs, Colorado A: Sit tight! The news about a fecal DNA test to spot hemoglobin and mutant DNA that might indicate the presence of colon cancer and adenomatous polyps (benign polyps that could turn cancerous) is great news, but it doesn’t eliminate the need for colonoscopies. It may, however, tell you that you need one! The DNA stool test is an exam for folks 50 and older who have an average risk of colon cancer. Its cost is covered by Medicare and Medicaid; they’re recommending that it be done every three years. Compared with the fecal immunochemical test (FIT), the DNA test is around 93 percent sensitive to 65 variations of malignancies; FIT rates just 73 percent. Also, it specifically detects precancerous lesions 42 percent of the time, while FIT detects only 23 percent. How you proceed with your regular screening for colon cancer depends on your risks and a discussion with your doctor. If you’ve already had a polyp found and removed during a colonoscopy, if anyone in your family has had colon cancer or adenomatous polyps, if you have irritable-bowel disease or genetic predispositions or if you are black or an Ashkenazi Jew, you may want to get the DNA stool test every year; you’ll need to have a colonoscopy as frequently as your doctor recommends. If you don’t have extra risk factors for colon cancer, you still may want to do the DNA test regularly and have a colonoscopy every 10 years after a base-line scope at age 50 (45 for blacks). Also, talk to your doc about taking two low-dose aspirins a day if you don’t take ’em already; they decrease the risk of colon cancer by over 35 percent. So, don’t postpone a recommended colonoscopy; it’s a life-saver. A polyp removed never becomes cancerous, and colon cancer caught early has a very good prognosis. Q: I have 27 vacation days piled up, and if I don’t take them, they’ll expire at the end of the year. I also can skip the time off and get paid for it. That seems smarter. What do you think? Susan B., New York A: You’re lucky to have paid vacation days; the U.S. is the only advanced country in the world that doesn’t guarantee workers paid vacations. (Every country in the EU mandates at least four weeks off annually.) So if you have days off, take them! You’ll be much happier and healthier, and a more productive employee. (One Cincinnati janitorial firm reduced its employee turnover rate from 360 percent to 60 percent and increased productivity by introducing a week’s vacation.) Unfortunately, many Americans are like you, Susan, and don’t take vacations even when they’re offered! American workers left an estimated 577,212,000 vacation days untaken in 2013! And if you do take time off, 67 percent of you are still in contact with your office. The 1950s had a vision of an automated future that gave you loads of free time. That future is here and what do you get from all that advanced technology? MORE TIME TO WORK MORE!

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Study: Test all women of Ashkenazi descent for BRCA defect

Image via Shutterstock.com All women of Ashkenazi descent should be screened from age 30 for the BRCA gene mutation that causes breast cancer, an Israeli study recommends. The study, by a research team headed by Ephrat Levy-Lahad of Shaare Zedek Medical Center, was published Friday in thejournalProceedings of the National Academy of Sciences of the United States of America. Until now, Ashkenazi women have been tested for the BRCA1 and BRCA2 genes only if a close blood relative had breast or ovarian cancer or were identified as carrying the gene. The research was conducted on a random group of Jewish women of Ashkenazi origin who did not necessarily have a family history of the disease. Many of the women identified during the study as being mutation carriers would not have known otherwise, according to the study. The mutation can be handed down to women through their fathers. We welcome your feedback. Privacy Policy Your information will not be shared or sold without your consent. Get all the details. Terms of Service JewishJournal.com has rules for its commenting community.Get all the details.

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New Study Recommends All Ashkenazi Women Be Screened for BRCA

1 in 40 Ashkenazi Jews Carries Gene Mutation By JTA Published September 08, 2014. All women of Ashkenazi descent should be screened from age 30 for the BRCA gene mutation that causes breast cancer, an Israeli study recommends. The study, by a research team headed by Ephrat Levy-Lahad of Shaare Zedek Medical Center, was published Friday in the journal Proceedings of the National Academy of Sciences of the United States of America. Until now, Ashkenazi women have been tested for the BRCA1 and BRCA2 genes only if a close blood relative had breast or ovarian cancer or were identified as carrying the gene. The research was conducted on a random group of Jewish women of Ashkenazi origin who did not necessarily have a family history of the disease. Many of the women identified during the study as being mutation carriers would not have known otherwise, according to the study. The mutation can be handed down to women through their fathers.

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September 8, 2014   Posted in: Ashkenazi  Comments Closed

New colon cancer test; vacation rewards

Q: I heard there is a DNA test for colon cancer. Can I cancel my colonoscopy? Please?! Stephen G., Colorado Springs, Colorado A: Sit tight! The news about a fecal DNA test to spot hemoglobin and mutant DNA that might indicate the presence of colon cancer and adenomatous polyps (benign polyps that could turn cancerous) is great news, but it doesn’t eliminate the need for colonoscopies. It may, however, tell you that you need one! The DNA stool test is an exam for folks 50 and older who have an average risk of colon cancer. Its cost is covered by Medicare and Medicaid; they’re recommending that it be done every three years. Compared with the fecal immunochemical test (FIT), the DNA test is around 93 percent sensitive to 65 variations of malignancies; FIT rates just 73 percent. Also, it specifically detects precancerous lesions 42 percent of the time, while FIT detects only 23 percent. How you proceed with your regular screening for colon cancer depends on your risks and a discussion with your doctor. If you’ve already had a polyp found and removed during a colonoscopy, if anyone in your family has had colon cancer or adenomatous polyps, if you have irritable bowel disease or genetic predispositions or if you are black or an Ashkenazi Jew, you may want to get the DNA stool test every year; you’ll need to have a colonoscopy as frequently as your doctor recommends. If you don’t have extra risk factors for colon cancer, you still may want to do the DNA test regularly and have a colonoscopy every 10 years after a baseline scope at 50 (45 for blacks). Also, talk to your doc about taking two low-dose aspirins a day if you don’t take em already; they decrease the risk of colon cancer by over 35 percent. So, don’t postpone a recommended colonoscopy; it’s a lifesaver. A polyp removed never becomes cancerous, and colon cancer caught early has a very good prognosis. Q: I have 27 vacation days piled up, and if I don’t take them, they’ll expire at the end of the year. I also can skip the time off and get paid for it. That seems smarter. What do you think? Susan B., New York A: You’re lucky to have paid vacation days; the U.S. is the only advanced country in the world that doesn’t guarantee workers paid vacations. (Every country in the EU mandates at least four weeks off annually.) So if you have days off, take them! You’ll be much happier and healthier, and a more productive employee. (One Cincinnati janitorial firm reduced its employee turnover rate from 360 percent to 60 percent and increased productivity by introducing a week’s vacation.) Unfortunately, many Americans are like you, Susan, and don’t take vacations even when they’re offered! American workers left an estimated 577,212,000 vacation days untaken in 2013! And if you do take time off, 67 percent of you are still in contact with your office. The 1950s had a vision of an automated future that gave you loads of free time. That future is here and what do you get from all that advanced technology? MORE TIME TO WORK MORE! Take advantage of your vacation time: Disconnect from stress; reconnect with your family, and protect your health. One study of middle-age men (at risk for heart disease) found that those who skipped vacations had a 30 percent higher risk of heart attack than guys who took at least a week off. And women who rarely take time off are eight times more likely to have a heart attack than women who take two vacations a year. Other studies prove that vacations improve marriages and are great times to try to upgrade your habits quitting smoking, getting more exercise, banishing the Five Food Felons.

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September 8, 2014   Posted in: Ashkenazi  Comments Closed

Who are the Ashkenazi Jews? (with pictures)

Why is it racism to tell the truth? Ashkenazi Jews claim by birthright they had a right to take Palestine and treat Palestinians as visitors. The promise God made to Abraham was not made to the sons of Japeth or Ham; it was made to Abraham and his sons, descendants of Shem. The Ashekenazi who say they are Jews by conversion have abandoned the principal way of determining a Jew’s heritage. All Old Testament lineages were traced through the father, not the mother. If a Christian says he/she is a Christian and hates their enemies, they are no more Christian than a Jew who says he/she is a Jew and traces their ancestry through women. The Ashekenazi have abandoned the daily sacrifice required by the Law and replaced it with the commandments of men and not God. It is said that prayers offered in the morning meet the requirement God requires of those that live under the Law. Clearly, that is not true. The Ashekenazi have allied themselves with idol worshippers and false prophets (the Mormons) and therefore not only have no birthright, but also have have set themselves apart from God. Every king and all false prophets in the Bible who allied with such were punished by the Lord. Mormons mask themselves as Christians, but are blasphemers and Ashekanazi have a lot of people fooled with their masks as well, but they are wolves in sheep’s clothing. They are the Jews who are not Jews in the Bible. You correctly said that if a person converts to Christianity, then it doesn’t matter what their Jewish ancestry is. But what does matter is that their works match their faith and that they do not pervert the inspired Word of God with man-made doctrines that exist to control others, benefit themselves, and are always fairly obvious because their fruits are always bad. It is not racism to say Ashekenazi are not Jews by promise, but as in Esther’s day, many Persians converted to Judaism out of fear and became Jews. The idea that Christians would ally themselves with a nation armed with 120 nukes crying about their neighbors who have not one single nuke because they believe God would have His temple on the blood soaked ground soaked with the blood of His Son is an anti-Christ dogma. Clearly, Paul and Revelation state there will be a new heaven and a new earth, and Zion will come out of that Heaven, not the polluted ruin that is covered with God’s Son’s blood. The Ashekenazi and false Christians have used this propaganda to profit from those poor souls that need to be freed. In this country where there is not supposed to be a religious test, let a politician say one word about the Ashekenazi or the home they stole, and that politician will never be elected. Yet our president can be called a monkey, a terrorist, the N word, and any other disgusting name and the politician who utters that evil is rewarded. I hardly think racism can be applied to the Ashekenazi who wield more power with less than 5 percent of the population of our nation of almost 300 million people. Lenin, Marx and Stalin — all engineers of mass murder and communism were all Ashekenazi Jews. I have heard that even Hitler was Ashkenazi. I don’t know.

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September 8, 2014   Posted in: Ashkenazi  Comments Closed

Ashkenazi Jewish Children on the rampage YouTube – Video




Ashkenazi Jewish Children on the rampage YouTube Ashkenazi Jewish Children on the rampage YouTube. By: AbortedBabysInMakeUp

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September 5, 2014   Posted in: Ashkenazi  Comments Closed

Angelina Jolie Effect Doubles BRCA Testing; @ProMedicaHealth Cancer Genetics Expert Discusses the Importance of …

Released: 5-Sep-2014 8:00 AM EDT Source Newsroom: ProMedica Contact Information Available for logged-in reporters only New research shows more women are getting tested for BRCA1 and 2 mutations after actress Angelina Jolie revealed she had undergone a prophylactic mastectomy once she found out she was a carrier. BRCA1 and 2 mutations dramatically increase the risk for breast and ovarian cancer. The mutations, which are found in about 2 4 percent of women, are more likely in those with a family history of breast and ovarian cancer and those with personal risk factors, such as Ashkenazi Jewish descent. Kelly Morse, a licensed genetic counselor at ProMedica Cancer Institute, says our family history plays a crucial role in our overall health and well-being. Keeping a file with information about your familys medical history should be a priority for everyone, Morse said. As a parent, passing down detailed notes about your ancestors health to your children can be an invaluable gift. Once a loved one is gone, it becomes very difficult to recall this vital data. Morse suggests patients begin with the following: 1. Start by making a list of your ancestors and immediate family members. It may be helpful to layout the information in a family tree format. Example: Grandparents Parents Siblings Children Aunts/Uncles Cousins 2. Next to each name write down any major health issues, especially cancer diagnoses in this case, and at what age. 3. It may also be helpful to include notes about your loved ones treatment journey. Including lab work and other tests can be especially helpful as well. These details can help tell the story and impact future care and treatment of you or your family.

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September 5, 2014   Posted in: Ashkenazi  Comments Closed


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